Nicole Sampson


		Nicole S. Sampson Professor B.S., 1985, Harvey Mudd College Ph.D., 1990, University of California, Berkeley American Cancer Society Postdoctoral Fellowship, Harvard University, 1991-1993; Camille and Henry Dreyfus Foundation New Faculty Award, 1993-98; National Science Foundation Career Award, 1996-2000; 2001 American Chemical Society Arthur C. Cope Scholar Award; 2005 American Chemical Society Pfizer Award in Enzyme Chemistry Tel: (631) 632 7952 Fax: (631) 632 5731 Email: nicole.sampson@sunysb.edu Publications Sampson Group Web Page


	CHEMICAL BIOLOGY Our research program focuses on proteins. How do they effect catalysis? How does the interaction of two or more proteins intiate a biological process? The methodologies utilized in our laboratory comprise a broad range of techniques; they include organic synthesis, enyzme kinetics, NMR spectroscopy and molecular biology. We are currently studying these systems: 1) The role of the ADAM proteins in mammalian fertilization. 2) The interactions of cholesterol oxidase with the lipid membrane, and the role of lipid structure in determining catalytic activity. 3) How the protein structure controls flavin redox activity in cholesterol oxidase. 4) Whether cholesterol oxidase is a pathogenic factor in Mycobacterium tuberculosis infection. 5) The role of protein hinge amino acid sequence and structure in triosephosphate isomerase Please visit the Sampson group web page for further information. Please visit the Sampson group web page for further information.